HY-13011 CH5424802（別名CH5424802）機制：ALK
價格和可用性CH5424802 CH5424802技術參數：
CH5424802 M.Wt：482.62
CH5424802分子式：C30H34N4O2
CH5424802純度：> 98％
CH5424802貯存：貯存在-20℃2年
CH5424802 CAS號：1256580-46-7
CH5424802溶解性：DMSO≥13mg/mL水分<1.2mg/mL乙醇1.2mg/mL
生物活性CH5424802：
CH5424802是一種強效，選擇性，可口服ALK抑制劑。它具有獨特的化學腳手架，優惠的抗腫瘤活性，對癌癥的ALK基因的改變，如非小細胞肺癌（NSCLC）細胞表達EML4-ALK融合和間變性大細胞**瘤（ALCL）細胞表達NPM-ALK融合在體內和體外。 CH5424802 ALK L1196M，對應網守突變賦予共同抵抗激酶抑制劑，抑制和阻斷EML4-ALK L1196M驅動的細胞生長。
HY-13011 CH5424802 (Synonyms CH 5424802) Mechanisms:ALK CH5424802 Technical Data: Price and Availability of CH5424802 CH5424802 M.Wt: 482.62 CH5424802 Formula: C30H34N4O2 CH5424802 Purity: >98% CH5424802 Storage: at -20℃ 2 years CH5424802 CAS No.: 1256580-46-7 CH5424802 Solubility: DMSO ≥13mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 5mg 10mg 25mg 50mg 200mg Biological Activity of CH5424802: CH5424802 is a potent, selective, and orally available ALK inhibitor. which with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.